Description
The NanoRam-1064 is a powerful handheld Raman Spectrometer. It helps identify and verify incoming raw materials. This includes APIs, excipients, and intermediates, no matter their color. The NanoRam-1064 is compact and user-friendly.
Non-technical users can quickly identify samples in various places. This includes the warehouse, loading ramp, field, or laboratory. It helps reduce quarantine areas and speeds up materials in the manufacturing process.
Using Raman technology, the NanoRam-1064 reduces fluorescence. It can identify many samples by distinguishing between different grades of cellulose, polysorbate, and Opadry.
You can test incoming materials quickly with the NanoRam-1064. This can be done through clear containers. It keeps the sample’s volume and integrity intact. The unit also offers full onboard library and method validation, making a compliant workflow for methods and library development.
The NanoRam-1064 is designed for rapid inspection of incoming materials at the point of need. Utilizing Raman technology, researchers can quickly and easily collect data through transparent containers, thereby maintaining the sample’s integrity. The high-performance NanoRam-1064 minimizes fluorescence and can effectively differentiate many excipients, including cellulose, polysorbate, and Opadry®, in addition to colored materials.
The NanoRam meets the US FDA 21 CFR Part 11 and Part 1040.10 standards. It can play an important role in cGMP-compliant facilities. The NanoRam-1064 meets the requirements of Raman spectroscopy methods, including the US Pharmacopeia <858>, European Pharmacopeia 2.2.48, Japanese Pharmacopeia 2.26, as well as the People’s Republic of China Pharmacopeia Directives on Raman Spectroscopy.
Raman spectroscopy is a well-established method for meeting PIC/S and GMP regulations. It ensures 100% identity assurance for starting materials.
You can find a full range of training courses and support services. This includes IQ, OQ, PQ, and DQ implementation services. We also offer assistance with method development and support for new libraries.
Key Features
- Non-destructive material identification and verification
- No sample preparation required
- Analysis through glass or plastic
- Fast, straightforward procedures
- Highly sensitive spectrometers with repeatable results
- Intuitive software with easy touchscreen operation
Easy Operation for Non-Technical Users
- Touch screen interface with simple 1-touch workflow
- Easy single-handed operation
- Batch mode for quick testing of multiple containers
- Interface available in multiple languages. Barcode scanner for quick method selection and product information entry
- LIMS compatible
Methodology and Instrumentation
Raman analysis is performed through transparent or opaque containers using a 1064 nm laser to reduce fluorescence interference. Key methodological features include:
- Through-container measurement preserves sample integrity and throughput.
- TE-cooled detector—ensures spectral stability across variable ambient temperatures.
- User-definable libraries and validation protocols—facilitate rapid method deployment and transferability.
- Multivariate pass/fail algorithms—leverage p-value statistics from reduced‐variable models for robust identification.
- Optional mixture analysis—for simultaneous detection of multiple components.
Used Instrumentation
The NanoRam-1064 system comprises:
- Excitation source: 1064 nm laser, adjustable output up to 420 mW in 10% increments.
- Spectral coverage: 176 cm⁻¹ to 2500 cm⁻¹.
- Detection: TE-cooled sensor for low-noise data acquisition.
- Interfaces: Bright touchscreen, onboard barcode reader (1D/2D), optional factory-enabled camera.
- Software: Embedded NOS-1064 is used for on-device operations. The PC-based NID EX handles data management, report generation, LIMS integration, and provides a full audit trail. It is compliant with 21 CFR Part 11.
- Connectivity: Secure Wi-Fi and USB synchronization to network servers.
- Sampling accessories: Point-and-shoot adaptor, vial holder, polystyrene validation cap, bottle and right-angle adaptors, immersion probe, large spot adaptor (optional).
Main Results and Discussion
Performance tests demonstrate:
- High data quality with minimal noise and fast measurement times, even for highly fluorescent or colored samples.
- Successful differentiation of structurally related compounds, such as cellulose variants, polysorbates, and coating agents (Opadry®).
- Reliable method validation and library transfer, reducing method activation time on new devices.
- Effective mixture analysis for complex samples through multivariate spectral deconvolution.
Benefits and Practical Applications
Key advantages include:
- Nontechnical user operation via intuitive touch workflow and one-touch pass/fail results.
- Elimination of quarantine zones by on-the-spot verification at loading docks, warehouses, or in the field.
- Full compliance with cGMP and international pharmacopeial standards (USP, EP, JP, ChP).
- Secure data handling supporting 21 CFR Part 11 requirements for electronic records and signatures.
Future Trends and Applications
Advancements in handheld Raman technology may include:
- Integration of cloud-based libraries and AI‐driven spectral matching for real-time global updates.
- Enhanced miniaturization to further reduce weight and improve ergonomics.
- Expanded chemometric toolsets for quantitative analysis and contaminant screening.
- Broader adoption in supply chain verification, counterfeit detection, and on-site environmental monitoring.
The NanoRam-1064 handheld Raman spectrometer provides a robust and user-friendly solution for rapid material identification in regulated environments. With advanced fluorescence suppression, versatile sampling options, and compliant software, it streamlines quality assurance workflows and supports 100% identity assurance for raw materials.
This particular system comes straight from the manufacturer, and BWTek, a trusted brand, makes it. It features a range of impressive aspects, including a powerful 1064-nanometer laser, high-quality spectrophotometers, and more. Don’t miss this great chance to improve your work with the B&W Tek BWTek NanoRam-1064 Portable Raman Spectrometer System!
